Scientists hail new antibiotic that can kill drug-resistant bacteria::Zosurabalpin has defeated strains of pneumonia and sepsis in mice, raising hopes for human trials

  • Uriel238 [all pronouns]@lemmy.blahaj.zone
    link
    fedilink
    English
    arrow-up
    6
    ·
    10 months ago

    We have way too many cases of XDRTB, often in impoverished, unindustrialized regions, so this is one of the outbreaks that needs some new treatments and a whole lot less corporate greed.

    At the moment, we can build custom bacteriaphages, but currently, solutions like this are largely concerned with the movement of small green pieces of paper (which is odd because on the whole it isn’t the small green pieces of paper that are sick.)

  • AutoTL;DR@lemmings.worldB
    link
    fedilink
    English
    arrow-up
    3
    ·
    10 months ago

    This is the best summary I could come up with:


    Scientists have discovered an entirely new class of antibiotic that appears to kill one of three bacteria considered to pose the greatest threat to human health because of their extensive drug-resistance.

    Zosurabalpin defeated highly drug-resistant strains of Carbapenem-resistant Acinetobacter baumannii (Crab) in mouse models of pneumonia and sepsis, and was being tested in human trials.

    “Crab is a significant cause of infection in hospitals, particularly in people who are on ventilators,” said Dr Andrew Edwards, a senior lecturer in molecular microbiology at Imperial College London, who was not involved in the research.

    Through a series of experiments published in Nature, Prof Daniel Kahne at Harvard University in Cambridge, US, and colleagues showed that the drug prevented LPS from being transported to the outer membrane of the bacterium, killing it.

    While he stressed that this molecule alone would not solve the public health threat of antimicrobial resistant infections, the discovery could lay the foundations for future efforts to drug the same transport system in other bacteria.

    It recommended that the government should consider establishing a small facility at the mothballed Rosalind Franklin laboratory in the West Midlands, which was originally set up to process Covid tests during the pandemic.


    The original article contains 624 words, the summary contains 198 words. Saved 68%. I’m a bot and I’m open source!